Weili Zheng (Lily)

I am a scientist using structural biology, biochemistry, molecular and cellular biology techniques to study the structure and function of protein complexes that play significant roles in many biological processes and diseases.

Publications with our group (see more on Google Scholar)

Tight-packing of large pilin subunits provides distinct structural and mechanical properties for the Anke Treuner-Lange, Weili Zheng, Albertus Viljoen, Steffi Lindow, Marco Herfurth, Yves F Dufrêne, Lotte Søgaard-Andersen, Edward H Egelman Published in Proceedings of the National Academy of Sciences of the United States of America, April 2024 (see publication)

Near-atomic-resolution structure of J-aggregated helical light-harvesting nanotubes. Arundhati P Deshmukh, Weili Zheng, Chern Chuang, Austin D Bailey, Jillian A Williams, Ellen M Sletten, Edward H Egelman, Justin R Caram Published in Nature chemistry, February 2024 (see publication)

Large pilin subunits provide distinct structural and mechanical properties for the Anke Treuner-Lange, Weili Zheng, Albertus Viljoen, Steffi Lindow, Marco Herfurth, Yves F Dufrêne, Lotte Søgaard-Andersen, Edward H Egelman Published in bioRxiv : the preprint server for biology, July 2023 (see publication)

Convergent evolution in the supercoiling of prokaryotic flagellar filaments. Mark A B Kreutzberger, Ravi R Sonani, Junfeng Liu, Sharanya Chatterjee, Fengbin Wang, Amanda L Sebastian, Priyanka Biswas, Cheryl Ewing, Weili Zheng, Frédéric Poly, Gad Frankel, B F Luisi, Chris R Calladine, Mart Krupovic, Birgit E Scharf, Edward H Egelman Published in Cell, September 2022 (see publication)

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity. Songyu Dong, Weili Zheng, Nicholas Pinkerton, Jacob Hansen, Svetlana B Tikunova, Jonathan P Davis, Sarah M Heissler, Elena Kudryashova, Edward H Egelman, Dmitri S Kudryashov Published in International journal of molecular sciences, July 2022 (see publication)

Allosteric regulation controls actin-bundling properties of human plastins. Christopher L Schwebach, Elena Kudryashova, Richa Agrawal, Weili Zheng, Edward H Egelman, Dmitri S Kudryashov Published in Nature structural & molecular biology, May 2022 (see publication)

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome. Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Zachary Mazanek, Naveen Mohideen, Albert Y Lau, Edward H Egelman, Jungsan Sohn Published in Nature communications, May 2021 (see publication)

Cryoelectron-microscopy structure of the enteropathogenic Escherichia coli type III secretion system EspA filament Weili Zheng, Alejandro Peña, Aravindan Ilangovan, Yasaman Naemi Baghshomali, Gad Frankel, Edward H Egelman, Tiago R D Costa Published in Proceedings of the National Academy of Sciences of the United States of America, January 2021 (see publication)

Cryoelectron-Microscopic Structure of the pKpQIL Conjugative Pili from Carbapenem-Resistant Klebsiella pneumoniae. Weili Zheng, Alejandro Pena, Wen Wen Low, Joshua L C Wong, Gad Frankel, Edward H Egelman Published in Structure (London, England : 1993), September 2020 (see publication)

Structures of filamentous viruses infecting hyperthermophilic archaea explain DNA stabilization in extreme environments. Fengbin Wang, Diana P Baquero, Leticia C Beltran, Zhangli Su, Tomasz Osinski, Weili Zheng, David Prangishvili, Mart Krupovic, Edward H Egelman Published in Proceedings of the National Academy of Sciences of the United States of America, August 2020 (see publication)

Osteogenesis imperfecta mutations in plastin 3 lead to impaired calcium regulation of actin bundling. Christopher L Schwebach, Elena Kudryashova, Weili Zheng, Matthew Orchard, Harper Smith, Lucas A Runyan, Edward H Egelman, Dmitri S Kudryashov Published in Bone research, June 2020 (see publication)

The AAA + ATPase TorsinA polymerizes into hollow helical tubes with 8.5 subunits per turn. F Esra Demircioglu, Weili Zheng, Alexander J McQuown, Nolan K Maier, Nicki Watson, Iain M Cheeseman, Vladimir Denic, Edward H Egelman, Thomas U Schwartz Published in Nature communications, July 2019 (see publication)

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus. Benjamin Bardiaux, Gisele Cardoso de Amorim, Areli Luna Rico, Weili Zheng, Ingrid Guilvout, Camille Jollivet, Michael Nilges, Edward H Egelman, Nadia Izadi-Pruneyre, Olivera Francetic Published in Structure (London, England : 1993), May 2019 (see publication)

Functional reconstitution of the type IVa pilus assembly system from enterohaemorrhagic Escherichia coli. Areli Luna Rico, Weili Zheng, Nathalie Petiot, Edward H Egelman, Olivera Francetic Published in Molecular microbiology, December 2018 (see publication)

Cryo-EM structure of the NLRC4 Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Brendan Antiochos, Edward H Egelman, Jungsan Sohn Published in The Journal of biological chemistry, November 2018 (see publication)

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions. Caitlin N Spaulding, Henry Louis Schreiber, Weili Zheng, Karen W Dodson, Jennie E Hazen, Matt S Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, Edward H Egelman Published in eLife, January 2018 (see publication)

Structure of the calcium-dependent type 2 secretion pseudopilus. Aracelys López-Castilla, Jenny-Lee Thomassin, Benjamin Bardiaux, Weili Zheng, Mangayarkarasi Nivaskumar, Xiong Yu, Michael Nilges, Edward H Egelman, Nadia Izadi-Pruneyre, Olivera Francetic Published in Nature microbiology, October 2017 (see publication)

Refined Cryo-EM Structure of the T4 Tail Tube: Exploring the Lowest Dose Limit. Weili Zheng, Fengbin Wang, Nicholas M I Taylor, Ricardo C Guerrero-Ferreira, Petr G Leiman, Edward H Egelman Published in Structure (London, England : 1993), August 2017 (see publication)