Mark Kreutzberger

Overview: I am currently a postdoc in the Egelman lab. I joined the lab in 2018 as a PhD student and worked structural studies of bacterial and archaeal flagellar filaments, nanotube assemblies from small peptides. For my postdoctoral work I am continuing to develop my expertise obtained during my PhD while expanding my focus to include new and exciting structures with a wide range of biological and medical implications.

Publications with our group

A Collagen Triple Helix without the Super Helical Twist. Mark A B Kreutzberger, Le Tracy Yu, Maria C Hancu, Michael D Purdy, Tomasz Osinski, Peter Kasson, Edward H Egelman, Jeffrey D Hartgerink Published in bioRxiv : the preprint server for biology, October 2024 (see publication)

Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM. Yijia Cheng, Mark A B Kreutzberger, Jianting Han, Edward H Egelman, Qin Cao Published in Nature communications, September 2024 (see publication)

Flagellar point mutation causes social aggregation in laboratory-adapted Safiya Alvi, V Denise Mondelo, Jacqueline Boyle, Amanda Buck, Justin Gejo, Molly Mason, Shriya Matta, Abigail Sheridan, Mark A B Kreutzberger, Edward H Egelman, Anna McLoon Published in Journal of bacteriology, September 2024 (see publication)

Two distinct archaeal type IV pili structures formed by proteins with identical sequence. Junfeng Liu, Gunnar N Eastep, Virginija Cvirkaite-Krupovic, Shane T Rich-New, Mark A B Kreutzberger, Edward H Egelman, Mart Krupovic, Fengbin Wang Published in Nature communications, June 2024 (see publication)

Beyond the Triple Helix: Exploration of the Hierarchical Assembly Space of Collagen-like Peptides. Le Tracy Yu, Mark A B Kreutzberger, Maria C Hancu, Thi H Bui, Adam C Farsheed, Edward H Egelman, Jeffrey D Hartgerink Published in bioRxiv : the preprint server for biology, May 2024 (see publication)

An extensive disulfide bond network prevents tail contraction in Agrobacterium tumefaciens phage Milano. Ravi R Sonani, Lee K Palmer, Nathaniel C Esteves, Abigail A Horton, Amanda L Sebastian, Rebecca J Kelly, Fengbin Wang, Mark A B Kreutzberger, William K Russell, Petr G Leiman, Birgit E Scharf, Edward H Egelman Published in Nature communications, January 2024 (see publication)

Neck and capsid architecture of the robust Agrobacterium phage Milano. Ravi R Sonani, Nathaniel C Esteves, Abigail A Horton, Rebecca J Kelly, Amanda L Sebastian, Fengbin Wang, Mark A B Kreutzberger, Petr G Leiman, Birgit E Scharf, Edward H Egelman Published in Communications biology, September 2023 (see publication)

Two dramatically distinct archaeal type IV pili structures formed by the same pilin. Junfeng Liu, Gunnar N Eastep, Virginija Cvirkaite-Krupovic, Shane T Rich-New, Mark A B Kreutzberger, Edward H Egelman, Mart Krupovic, Fengbin Wang Published in bioRxiv : the preprint server for biology, August 2023 (see publication)

The evolution of archaeal flagellar filaments. Mark A B Kreutzberger, Virginija Cvirkaite-Krupovic, Ying Liu, Diana P Baquero, Junfeng Liu, Ravi R Sonani, Chris R Calladine, Fengbin Wang, Mart Krupovic, Edward H Egelman Published in Proceedings of the National Academy of Sciences of the United States of America, July 2023 (see publication)

An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments. Marko Nedeljković, Mark A B Kreutzberger, Sandra Postel, Daniel Bonsor, Yingying Xing, Neil Jacob, William J Schuler, Edward H Egelman, Eric J Sundberg Published in PLoS pathogens, May 2023 (see publication)

Hollow Octadecameric Self-Assembly of Collagen-like Peptides. Le Tracy Yu, Maria C Hancu, Mark A B Kreutzberger, Amy Henrickson, Borries Demeler, Edward H Egelman, Jeffrey D Hartgerink Published in Journal of the American Chemical Society, February 2023 (see publication)

Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery. Leticia C Beltran, Virginija Cvirkaite-Krupovic, Jessalyn Miller, Fengbin Wang, Mark A B Kreutzberger, Jonasz B Patkowski, Tiago R D Costa, Stefan Schouten, Ilya Levental, Vincent P Conticello, Edward H Egelman, Mart Krupovic Published in Nature communications, February 2023 (see publication)

Convergent evolution in the supercoiling of prokaryotic flagellar filaments. Mark A B Kreutzberger, Ravi R Sonani, Junfeng Liu, Sharanya Chatterjee, Fengbin Wang, Amanda L Sebastian, Priyanka Biswas, Cheryl Ewing, Weili Zheng, Frédéric Poly, Gad Frankel, B F Luisi, Chris R Calladine, Mart Krupovic, Birgit E Scharf, Edward H Egelman Published in Cell, September 2022 (see publication)

Phenol-soluble modulins PSMα3 and PSMβ2 form nanotubes that are cross-α amyloids. Mark A B Kreutzberger, Shengyuan Wang, Leticia C Beltran, Abraham Tuachi, Xiaobing Zuo, Edward H Egelman, Vincent P Conticello Published in Proceedings of the National Academy of Sciences of the United States of America, May 2022 (see publication)

Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome. Fengbin Wang, Virginija Cvirkaite-Krupovic, Matthijn Vos, Leticia C Beltran, Mark A B Kreutzberger, Jean-Marie Winter, Zhangli Su, Jun Liu, Stefan Schouten, Mart Krupovic, Edward H Egelman Published in Cell, March 2022 (see publication)

Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. Mark A B Kreutzberger, Richard C Sobe, Amber B Sauder, Sharanya Chatterjee, Alejandro Peña, Fengbin Wang, Jorge A Giron, Volker Kiessling, Tiago R D Costa, Vincent P Conticello, Gad Frankel, Melissa M Kendall, Birgit E Scharf, Edward H Egelman Published in Nature communications, March 2022 (see publication)

Atomic structure of the Campylobacter jejuni flagellar filament reveals how ε Proteobacteria escaped Toll-like receptor 5 surveillance Mark A B Kreutzberger, Cheryl Ewing, Frederic Poly, Fengbin Wang, Edward H Egelman Published in Proceedings of the National Academy of Sciences of the United States of America, July 2020 (see publication)

Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. Spencer A Hughes, Fengbin Wang, Shengyuan Wang, Mark A B Kreutzberger, Tomasz Osinski, Albina Orlova, Joseph S Wall, Xiaobing Zuo, Edward H Egelman, Vincent P Conticello Published in Proceedings of the National Academy of Sciences of the United States of America, July 2019 (see publication)

An extensively glycosylated archaeal pilus survives extreme conditions. Fengbin Wang, Virginija Cvirkaite-Krupovic, Mark A B Kreutzberger, Zhangli Su, Guilherme A P de Oliveira, Tomasz Osinski, Nicholas Sherman, Frank DiMaio, Joseph S Wall, David Prangishvili, Mart Krupovic, Edward H Egelman Published in Nature microbiology, May 2019 (see publication)